%PDF-1.4
%
418 0 obj
<>>>
endobj
415 0 obj
<>stream
doi:bmjopen-2018-023191
application/pdf
2019-01-03T11:18:14Z
2023-02-07T06:56:52-08:00
2023-02-07T06:56:52-08:00
Adobe InDesign CS6 (Windows)
uuid:6977fd32-1dd2-11b2-0a00-8800084c9aff
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
xmp.id:6A2A2A40490FE9118850A8540FC1D479
proof:pdf
xmp.iid:692A2A40490FE9118850A8540FC1D479
xmp.did:12BEE6AC550DE8118634A2E26D244B8E
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CS6 (Windows)
/
2019-01-03T11:18:14Z
9ecb5d46-13b7-485f-badc-ae10f0c90d9d
Adobe PDF Library 10.0.1
False
endstream
endobj
419 0 obj
<>
endobj
316 0 obj
<>
endobj
412 0 obj
<>
endobj
413 0 obj
<>
endobj
414 0 obj
<>
endobj
53 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
64 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
71 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
92 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
121 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
188 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
197 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
204 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
211 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
230 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
231 0 obj
[232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 560 0 R]
endobj
557 0 obj
<>stream
HWrum跀)qE*vV#eKN `(L\P~> BRlQgϜ~7<-§o^t-&Y4,><>"3l`Xpd 3N?<
|EOwEG˻1u,CX\G,mt~~E==}.N)OgOeY,<#+2.>F<:]2b%x()?eEU.<(&~ yOb3+P2.^7
|c!^VZ/9M#9ny Hiy(";us\$D̈́;O yUy~=Qdy]j;^b;Y;6K#YMbJKT3}剘csJM"CK'LHQ"2(t+ԙU9kk}GKg[KE*dCAKThk`pqeXUΛ*Ó
^t]a7NKcnٱ+%d a*B!~B mJNy\I3R,2ު#r|c^% facrmHP]>h=]& <;"x3$SIRewmo3}"NWWM"Oi1/[nܕ
e1JV!ַΊм*qbNvM
d&kPpJ)RZVZh8s
%?@aδ<~^ PHP5pE
eqq%┣)y~mG`99觍-SCMac)5?:<ܢ᧽arߘmEA[?~hh]fEa?ʫ>H[mq7\;y'[Lo9:95&/ Oߟ>?1>XbIu5aǧs+,>oƒl@[Jx+8f4?H4AK?֟m})>e
&l-xS7_ ¢9x
ykJftq@eJ{z1.ڭ5qсL9 &=}-,+^çC̔'FH4)ɤ_]cL{y= FKxߊrQ0\0$d]!2LɃz/p\IFoIKlbpPI>` IkJ6I0fϹx*V ۴:=\g?dqk>ɹs]Yk?EQ*%})R}<NjםguqEqt,78F-?XoT2starsE2ٽĠ/}͋`!g4e;1IVu q2K#'¤GjlFǞK<'-5Ȋ,ښ^;`vO1-fbXsEs;퀖tjz .FAUs{jW#WUyQŊѼT&4-FoLrI-+OE*-gEsA:C{̲tvWruBelή3
SĕF\4ATZ·`h
d5?p)-
)1㚗k=|2!R.
=q(⃬xx][OWk߹1[kϹHuoJIC˛{Bg*NvkҶB&=M vhhtT\4h;i[NxO5<фwoޚD1tQ;ܕbfqBڋmGH=|Ey";V#4m{OGѰrVKJ353=b;W4+d
mH 4%p`ٽ0=S@#ϳ]o扃4-jE{օŗNYMDTVE&)YT% 0b^Η+
bEV]cycop>uهHDƮ:T9nܭ5wB
{G\OD ڑ#Pd4~`>`_
l%75/)\sTp*,VR$Kk-XτV[<]wߏ;f;իO`]v+ c}a*\T)8\p/2JUx^4{#ws
B%A9nc`O4-wZ&vr~.\1#M)lkK n E2){.kGxdc_k*0HȜ6ŔTɅh)6$4h~g
j&8=ED$JICX"i\Ao ^H6DHM,A\rfbDyf;UK)k^Kr4_-ɰZi`{gÙcFG ySL'~
b1!D"_`.Lm
dYxvyhH<@V+O
SLn&`@8Wk=X?vH
D/m$2/ C%L4v&4ٿ
SQhjZ|}&5[ŮbfC< Rx8
c3ledbS]D X8JF4=US!Fz;2pqb&7H(\, 4|4 !!S;xOxc_lcںs.
ɚoX{Z/ b8`nXjش)~ n#+i ~e1!RGqicxo&'ўvNwAt\(`(vΔbx\aU,.a@wj$S֖ӽ.jMdFBK9:Z<1EڄuG.DmC6źF/:!4v3YVp0N*LǻHm->s0CykTxjG|d[Zpf.TЬ%\=QZ1hwbV
<ȪZ35u< "LAR%4
J|5m#Τj&ZaOXL3X,V2Rf}Ǘ""J.3rьF
xl
Zu:?
\Sܷ`۬F~[q v<^HƼH|ŝüm"Uښ MRr .,^z~t`ڸ4ݾk&(
_[/xBZLS;H"f4l<kܔ97Q'jEQѼ5ݥ (~U )lTSL"Υ8
mN
lFEϡM14˲vifLimY.6NCg5m-wOie]]w]S~H%»f
\#)0REJYc
eksS`Bw_ߋ÷s+^Ŧ
Sٴvqr,T8ǣgCk4qC[|vqD7Yqk;CgDAiXrSW3}=3xz5;/\O],@z
z{MDR4J F@.HB yS=:?3|^
)1{v2F?l0D"FE(bfs14~jŅ%Mzt7R5bڽF_sdYmܢ[Q_jg(C{ԧvȏiB`_h),WS hTkKݨmRqh)P/!b<RzQTΕv%zg!~+1Aĸjz|H-յ^FSEOΒUp0&ɀeռWⓜ fSu8J6hPPc(PȲ<e,ĢJƃVP_̞4n/}gDa\e Ɣvăm=[kgc kfvaR؍$jG#6u(+Ʊ
"_4?\j